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The physicist, in his study of natural phenomena, has two methods of making progress: (1) the method of experiment and observation, and (2) the method of mathematical reasoning. The former is just the collection of selected data; the latter enables one to infer results about experiments that have not been performed. There is no logical reason why the second method should be possible at all, but one has found in practice that it does work and meets with reasonable success. This must be ascribed to some mathematical quality in Nature, a quality which the casual observer of Nature would not suspect, but which nevertheless plays an important role in Nature's scheme. One might describe the mathematical quality in Nature by saying that the universe is so constituted that mathematics is a useful took in its description. However, recent advances in physical science show that this statement of the case is too trivial. The connection between mathematics and the description of the universe goes far deeper than this, and one can get an appreciation of it only from a thorough examination of the various facts that make it up. The main aim of my talk to you will be to give you such an appreciation. I propose to deal with how the physicist's views on this subject have been gradually modified by the succession of recent developments in physics, and then I would like to make a little speculation about the future. Let us take as our starting-point that scheme of physical science which was generally accepted in the last century - the mechanistic scheme. This considers the whole universe to be a dynamical system (of course an extremely complicated dynamical system), subject to laws of motion which are essentially of the Newtonian type. The role of mathematics in this scheme is to represent the laws of motion by equations, and to obtain solutions of the equations referring to observed conditions. The dominating idea in this application of mathematics to physics is that the equations representing the laws of motion should be of a simple form. The whole success of the scheme is due to the fact that equations of simple form do seem to work. The physicist is thus provided with a principle of simplicity, which he can use as an instrument of research. If he obtains, from some rough experiments, data which fit in roughly with certain simple equations, he infers that if he performed the experiments more accurately he would obtain data fitting in more accurately with the equations. The method is much restricted, however, since the principle of simplicity applies only to fundamental laws of motion, not to natural phenomena in general. For example, rough experiments about the relation between the pressure and volume of a gas at a fixed temperature give results fitting in with a law of inverse proportionality, but it would be wrong to infer that more accurate experiments would confirm this law with greater accuracy, as one is here dealing with a phenomenon which is not connected in any very direct way with the fundamental laws of motion. The discovery of the theory of relativity made it necessary to modify the principle of simplicity. Presumably one of the fundamental laws of motion is the law of gravitation which, according to Newton, is represented by a very simple equation, but, according to Einstein, needs the development of an elaborate technique before its equation can even be written down. It is true that, from the standpoint of higher mathematics, one can give reasons in favour of the view that Einstein's law of gravitation is actually simpler than Newton's, but this involves assigning a rather subtle meaning to simplicity, which largely spoils the practical value of the principle of simplicity as an instrument of research into the foundations of physics. What makes the theory of relativity so acceptable to physicists in spite of its going against the principle of simplicity is its great mathematical beauty. This is a quality which cannot be defined, any more than beauty in art can be defined, but which people who study mathematics usually have no difficulty in appreciating. The theory of relativity introduced mathematical beauty to an unprecedented extent into the description of Nature. The restricted theory changed our ideas of space and time in a way that may be summarised by stating that the group of transformations to which the space-time continuum is subject must be changed from the Galilean group to the Lorentz group. The latter group is a much more beautiful thing than the former - in fact, the former would be called mathematically a degenerate special case of the latter. The general theory of relativity involved another step of a rather similar character, although the increase in beauty this time is usually considered to be not quite so great as with the restricted theory, which results in the general theory being not quite so firmly believed in as the restricted theory. We now see that we have to change the principle of simplicity into a principle of mathematical beauty. The research worker, in his efforts to express the fundamental laws of Nature in mathematical form, should strive mainly for mathematical beauty. He should still take simplicity into consideration in a subordinate way to beauty. (For example Einstein, in choosing a law of gravitation, took the simplest one compatible with his space-time continuum, and was successful.). It often happens that the requirements of simplicity and of beauty are the same, but where they clash the latter must take precedence. Let us pass on to the second revolution in physical thought of the present century - the quantum theory. This is a theory of atomic phenomena based on a mechanics of an essentially different type from Newton's. The difference may be expressed concisely, but in a rather abstract way, by saying that dynamical variables in quantum mechanics are subject to an algebra in which the commutative axiom of multiplication does not hold. Apart from this, there is an extremely close formal analogy between quantum mechanics and the old mechanics. In fact, it is remarkable how adaptable the old mechanics is to the generalization of non-commutative algebra. All the elegant features of the old mechanics can be carried over to the new mechanics, where they reappear with an enhanced beauty. Quantum mechanics requires the introduction into physical theory of a vast new domain of pure mathematics - the whole domain connected with non-commutative multiplication. This, coming on top of the introduction of new geometries by the theory of relativity, indicates a trend which we may expect to continue. We may expect that in the future further big domains of pure mathematics will have to be brought in to deal with the advances in fundamental physics. Pure mathematics and physics are becoming ever more closely connected, though their methods remain different. One may describe the situation by saying that the mathematician plays a game in which he himself invents the rules while the physicist plays a game in which the rules are provided by Nature, but as time goes on it becomes increasingly evident that the rules which the mathematician finds interesting are the same as those which Nature has chosen. It is difficult to predict what the result of all this will be. Possibly, the two subjects will ultimately unify, every branch of pure mathematics then having its physical application, its importance in physics being proportional to its interest in mathematics. At present we are, of course, very far from this stage, even with regard to some of the most elementary questions. For example, only four-dimensional space is of importance in physics, while spaces with other numbers of dimensions are of about equal interest in mathematics. It may well be, however, that this discrepancy is due to the incompleteness of present-day knowledge, and that future developments will show four-dimensional space to be of far greater mathematical interest than all the others. The trend of mathematics and physics towards unification provides the physicist with a powerful new method of research into the foundations of his subject, a method which has not yet been applied successfully, but which I feel confident will prove its value in the future. The method is to begin by choosing that branch of mathematics which one thinks will form the basis of the new theory. One should be influenced very much in this choice by considerations of mathematical beauty. It would probably be a good thing also to give a preference to those branches of mathematics that have an interesting group of transformations underlying them, since transformations play an important role in modern physical theory, both relativity and quantum theory seeming to show that transformations are of more fundamental importance than equations. Having decided on the branch of mathematics, one should proceed to develop it along suitable lines, at the same time looking for that way in which it appears to lend itself naturally to physical interpretation. This method was used by Jordan in an attempt to get an improved quantum theory on the basis of an algebra with non-associative multiplication. The attempt was not successful, as one would rather expect, if one considers that non-associative algebra is not a specially beautiful branch of mathematics, and is not connected with an interesting transformation theory. I would suggest, as a more hopeful-looking idea for getting an improved quantum theory, that one take as basis the theory of functions of a complex variable. This branch of mathematics is of exceptional beauty, and further, the group of transformations in the complex plane, is the same as the Lorentz group governing the space-time of restricted relativity. One is thus led to suspect the existence of some deep-lying connection between the theory of functions