Engineering tough blood clots for rapid haemostasis and enhanced regeneration

Data availabilityAll data supporting the findings of this study are provided in the paper, the Extended Data and the Supplementary Information. Additional raw data generated in this study are available from the corresponding authors upon reasonable request.Code availabilityThe code that produced the findings of this study is available at GitHub (https://github.com/labofsoftbiomaterials/Engineered-blood-clot).ReferencesGuo, B., Dong, R., Liang, Y. & Li, M. Haemostatic materials for wound healing applications. Nat. Rev. Chem. 5, 773–791 (2021).Article  CAS  PubMed  Google Scholar  Weisel, J. W. Enigmas of blood clot elasticity. Science 320, 456–457 (2008).Article  CAS  PubMed  Google Scholar  Jiang, S., Liu, S., Lau, S. & Li, J. Hemostatic biomaterials to halt non-compressible hemorrhage. J. Mater. Chem. B 10, 7239–7259 (2022).Article  CAS  PubMed  Google Scholar  Bao, G. et al. Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage. Nat. Commun. 13, 5035 (2022).Article  ADS  CAS  PubMed  PubMed Central  Google Scholar  Yuk, H. et al. Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue. Nat. Biomed. Eng. 5, 1131–1142 (2021).Article  CAS  PubMed  PubMed Central  Google Scholar  Ovsianikov, A., Khademhosseini, A. & Mironov, V. The synergy of scaffold-based and scaffold-free tissue engineering strategies.

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